Well, after two weeks results are mixed.
In my three tier 1 leagues (two ESPN cash leagues and a yahoo league, all with my co-workers) I am 5-1. In the league I have a loss in, none of the teams in my division are undefeated.
In my three tier 2 leagues, I am 1-5 (three yahoo leagues with friends and former high school classmates) . That means I am .500 overall, not too shabby at this point.